The key receptor involved with the suppression of the cough response in the larynx, trachea and bronchus, the P2X3 receptor, has a closely related receptor on the taste buds, the P2X2/3 receptor, as shown in Figure 2. BLU 5937 has an IC50 for the cough receptor at concentrations in the low nanomolar range and an IC50 for the taste receptor in the mid micromolar range; while MK 7264 has an IC50 for the cough receptor at concentrations in the mid nanomolar range and an IC50 for the taste receptor in the high nanomolar range (Source: Company presentation). This difference allows the Company a wider dose range for cough suppression prior to blocking the receptor involved with taste.
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